Then one of two rival "secondary factors" activates the genes that lead to one cell type and shuts down the genes that lead to the alternative. 然后两个具有竞争性质的“次级信号”之一激活产生一类细胞的基因表达,同时抑制产生另一类细胞的基因表达。
The alarm bell halts the process of cell division in its tracks, preventing an error that could lead to runaway cell division and eventually, tumor formation. 警报使细胞分裂停止,以防止可能引起细胞分裂失控&最终导致肿瘤形成的错误发生。
"Fat makes extra hormones, which lead to extra cell activity and extra abnormal cell activity," she said. 脂肪产生额外的激素,这又引起额外的细胞活性和额外的不正常的细胞活性,她说。
Conclusions: Local deep vein thrombosis can lead to endothelial cell injury and early apoptosis of distant vein segment. 结论:局部深静脉血栓可以导致其他远隔部位静脉内皮细胞损伤,易发生早期凋亡。
This can lead to B cell hyperplasia and cancer. 这可导致B细胞的增生和癌症。
Change of DNA structure that came from α-ray, X-ray, γ ray and ultra-violet rays can lead to cell mutation. α射线、X射线、γ射线、紫外线等辐射因子对DNA结构造成的任何改变都可能导致细胞突变、癌变甚至死亡。
We adopt the partial shield lead cell, so that the primary X-ray outside the useful beam decreases to about 10~ (-4). 在对南京大学20Mev电子直线加速器实验室设计中:1.采用了局部铅屏蔽室,使有用束外的初级x线减弱至10~(-4)左右。
Moreover, stimulation of B cells with LPS or stimulation of T cells with IL-2 and Con A did not result in a growth disadvantage for the transgenic lymphocytes, nor did it lead to increased cell death. 此外,LPS对B细胞的激活或IL-2和conA对T细胞的刺激,不导致转基因淋巴细胞的生长劣势,亦不导致细胞死亡效应的增加。
The later research should be focused on further study on the modification of synthetic scaffolds ′ surface bioactivity and further enhancing the function of synthetic scaffolds to lead cell behavior and promoting cells adhesion on scaffolds by surface bionics technique; 今后应重点研究以下内容:深入研究合成支架材料的表面改性,进一步提高其引导细胞行为的功能,促进材料对细胞的黏附;
The genes also control enzyme action and cell organs change, in this case finally lead to cell death. 基因调控细胞内的酶活动,细胞器产生变化,导致细胞死亡。
Brain injury may lead to neuronal cell necrosis. 脑损伤可导致神经细胞坏死。
Ionizing radiation ( IR) can lead to cell/ tissue damage by many mays, among of which DNA double-strand breaks induced by IR is the key way to kill cell. 电离辐射能够通过多种方式诱导细胞或组织损伤,其中诱导DNA双链断裂是辐射杀死细胞的主要方式。
Cell apoptosis was closely related to the generation of the rumour because of the oncogene activation or anti-oncogene inactivation which could lead the cell cycle out of control. 细胞凋亡与肿瘤的发生密切相关,由于癌基因激活或抑癌基因失活导致的细胞周期失控,细胞凋亡不足,是许多肿瘤发生的重要机制。
When the structure and function of centrosome is abnormality, it will cause cell mitosis abnormality and cell polarity disorder, lead to cell chromosome instability ( CIN), and at last result in malignant tumor. 当中心体的结构和功能异常时,可引起细胞有丝分裂异常和细胞极性紊乱,并导致细胞染色体不稳(chromosomeinstability,CIN),最终导致恶性肿瘤的发生。
Several seperated method, such as flow-sorting and magnetic sorting et al, had been used to enrich for NRBCs, However, enrichment procedures inevitably lead to cell loss. the procedure breaks the law; 目前用于分离胎儿细胞的方法很多,如流式细胞仪分选和/或磁激活细胞分选法富集等,然而这些富集程序不可避免的导致细胞的丢失。
ROS can react with almost every critical cellular macromolecule, including DNA, lipid, protein, and carbohydrates, and cause functional as well as structural alterations in these biomolecules, which ultimately lead to cell death and tissue damage. ROS可与细胞内几乎所有的重要大分子(DNA、蛋白质、碳水化合物和脂质)发生反应,引起这些生物分子结构和功能改变,最终导致细胞死亡和组织损伤。
SO2 exposure could cause visible foliar damage such as chlorosis and necrosis, inhibit cell division, induce micronucleus, and lead to cell death. 高浓度的SO2能造成植物叶片失绿或坏死,抑制细胞分裂,诱导微核形成,导致部分细胞死亡。
The OH · could damage proteins, nucleus and mounts of unsaturated fatty acids, which could finally lead to cell death. OH·通过损伤蛋白质、核酸、和含有大量未饱和脂肪酸的细胞膜,最终导致细胞死亡。
If DNA damage can not be repaired in time, it would lead to cell proliferation and cause cancer. 如果DNA损伤不能得到及时修复,将导致细胞异常增殖,引起肿瘤的发生。
Overexpression of protein tyrosine kinases can activate downstream signaling pathways, which could lead to cell transformation, proliferation, anti-apoptosis and promotion of cell survival, eventually tumor occurrence. 蛋白酪氨酸激酶的过度表达激活其下游信号通路,从而导致细胞转化、增殖、对抗细胞凋亡、促进细胞生存,最终导致肿瘤的形成。
Excess in reactive oxygen species, such as superoxide anion radical or hydrogen peroxide, has harmful effects on DNA which may lead to cell apoptosis. 活性氧过多如超氧阴离子、过氧化氢,会对DNA造成损伤而使细胞凋亡。
Some signaling pathways are centered on a few of transcription factors, which are the final 'switches' that ultimately lead to cell malignant transformation. 一些肿瘤信号传导通路集中于有限的几个核转录因子,成为导致细胞恶性转化的最终开关。
ROS can lead to cell death by either necrosis or apoptosis, depending on the intensity of the oxidative stimuli. 根据氧化刺激的强度不同ROS能够引起细胞凋亡或坏死。
Ras gene is a kind of proto-oncogene in normal cells which has a close relation with proliferation and differentiation of cells. Continuing activation of ras gene will lead to cell proliferation and cause immortal cells. ras基因是存在于正常细胞的原癌基因,与细胞的增殖、分化有密切的关系;ras基因的持续的激活可导致细胞的增殖和永生化。
Objective: The constant generation and accumulation of free radicals in cells would damage the structure and function of proteins and nucleic acids, and thus lead to cell senescence or aging of the body, which is called the free radical theory of aging. 研究目的:衰老自由基学说认为机体组织细胞产生的自由基不断积累损伤蛋白质、核酸进而引起结构和功能的退行性变化,最终导致机体或细胞衰老发生。
These proinflammatory or reactive oxidative species-induced cascade formed into a deleterious loop which finally lead to cell injury or death. 这些前炎症细胞因子或活性氧化分子所形成的瀑布效应形成恶性循环,最后导致神经元的损伤或死亡。
Ionizing radiation ( IR) can induces a lot of genes and proteins expression and lead to cell/ tissue damage. 电离辐射能够诱导一系列基因和蛋白表达的改变,最后导致细胞或组织损伤。
Paclitaxel was a new natural broad-spectrum anti-tumor drug, by which the mechanism of apoptosis induced was to lead to cell cycle arrest in G2/ M phase mainly by restraining mitosis of cells, thus the normal mitosis of cells and cell multiplication were interrupted. 紫杉醇是一种新型天然广谱抗肿瘤药物,其诱导凋亡的机制主要是通过抑制细胞有丝分裂,使细胞阻滞于G2/M期,从而阻断正常的有丝分裂和细胞增殖。